by Marcus Hermansson | Nov 25, 2025 | "Science", Cardiovascular & Stroke, Medicine
Intro Over the last weeks I’ve been working on a slightly unhinged idea: What if we treated stroke not just as a plaque problem, but as a microvascular fatigue problem we can measure with ultrasound? Ultrasound localization microscopy (ULM) already lets us see...
by Marcus Hermansson | Nov 25, 2025 | "Science", Medicine, Oncology
Part 3 of a trilogy This post is essentially Part 3 in a trilogy: Paracetamol:Paracetamol’s braided mechanism – how we finally closed a 138-year pharmacology...
by Marcus Hermansson | Nov 24, 2025 | "Science", Medicine, Pharmacology & Pain
TL;DR:Paracetamol (acetaminophen) was supposed to be “simple” – a mild painkiller and fever reducer. Mechanistically it’s been a mess for over a century. What drops out of the data once you line everything up is: It’s not one mechanism. It’s a braid of four central...
by Marcus Hermansson | Nov 13, 2025 | "Science", Medicine, Neurology & Dementia
From (DISSAD → DISSAD+) In Part 1 (2025-08-14) I described how a “lithium” sidewalk moment in April 2024 turned into a testable Alzheimer’s model: DISSAD — Default-Mode Network Ion Seed-and-Sink in Alzheimer’s Disease The short version: Amyloid plaques in DMN hubs act...
by Marcus Hermansson | Sep 16, 2025 | "Science", Engineering & Materials, Medicine, Oncology
TL;DR We propose an inhalable nanoparticle system that biases toward lung-tumor regions (via pH-sensitive retention) and, when exposed to clinical X-rays, polymerizes in situ into a thin hydrogel “mesh.” The intended role is adjunctive: help limit cell shedding at...
by Marcus Hermansson | Aug 14, 2025 | "Science", Medicine, Neurology & Dementia
Phase 1 — The Spark (April 2024) It didn’t start in a lab.It started on a sidewalk. I’d been deep in Alzheimer’s research for a while — tracing the disease from the molecular chaos of amyloid-β plaques and tau tangles, to the inflammation, oxidative stress, and...
