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“Science”

Mapping Microvascular Stress: Our New OSF Project on Stroke-Risk ULM

Mapping Microvascular Stress: Our New OSF Project on Stroke-Risk ULM

by Marcus Hermansson | Nov 25, 2025 | "Science", Cardiovascular & Stroke, Medicine

Intro Over the last weeks I’ve been working on a slightly unhinged idea: What if we treated stroke not just as a plaque problem, but as a microvascular fatigue problem we can measure with ultrasound? Ultrasound localization microscopy (ULM) already lets us see...
From Paracetamol and Alzheimer’s Loops to a Minimal Viable Cancer Loop (MVCL)

From Paracetamol and Alzheimer’s Loops to a Minimal Viable Cancer Loop (MVCL)

by Marcus Hermansson | Nov 25, 2025 | "Science", Medicine, Oncology

Part 3 of a trilogy This post is essentially Part 3 in a trilogy: Paracetamol:Paracetamol’s braided mechanism – how we finally closed a 138-year pharmacology...
Paracetamol’s Braided Mechanism: How We Finally Closed a 138-Year Pharmacology Puzzle

Paracetamol’s Braided Mechanism: How We Finally Closed a 138-Year Pharmacology Puzzle

by Marcus Hermansson | Nov 24, 2025 | "Science", Medicine, Pharmacology & Pain

TL;DR:Paracetamol (acetaminophen) was supposed to be “simple” – a mild painkiller and fever reducer. Mechanistically it’s been a mess for over a century. What drops out of the data once you line everything up is: It’s not one mechanism. It’s a braid of four central...
Unified Field Theory of the Large Language Manifold

Unified Field Theory of the Large Language Manifold

by Marcus Hermansson | Nov 17, 2025 | "Science", Computer Science & AI, Social & Behavioral Science

The Large Language Manifold A New Lens on Language and Cognition We keep pretending the interesting object is “the model”: a big neural net in a datacenter that you poke with prompts and read answers from. That picture is already obsolete. As soon as we plugged these...
From a testable Alzheimer’s model to an Ion-Terrain map of dementia

From a testable Alzheimer’s model to an Ion-Terrain map of dementia

by Marcus Hermansson | Nov 13, 2025 | "Science", Medicine, Neurology & Dementia

Changelog / Status update: April 15, 2026 This post is an earlier public snapshot of the DISSAD framework. The core trunk/fork model still holds, but the chemistry has since been refined. The Alzheimer’s “Li-sink” should now be read as a non-ideal charged...
The Geometry of Wisdom in Artificial Minds

The Geometry of Wisdom in Artificial Minds

by Marcus Hermansson | Nov 10, 2025 | "Science", Computer Science & AI

Changelog / Version history: Update (Nov 29, 2025) These posts are early geometry probes (intuition/creativity/wisdom) written before the project switched to a more general string-theory operator toolkit for the same underlying operations (multi-scale flow,...
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